Gene name: ARG5,6
Reference locus (S288C): YER069W
Gene biotype: protein_coding
Description: Protein ARG5,6, mitochondrial; Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
Top 10 interactors (score): ARG3 (0.999); ARG7 (0.999); ARG1 (0.999); ARG4 (0.999); ARG8 (0.999); ARG2 (0.998); CPA2 (0.99); CPA1 (0.985); BIO3 (0.98); CAR1 (0.979); HIS4 (0.977); CAR2 (0.963); ORT1 (0.952); TRP3 (0.947); TRP5 (0.942); PRO2 (0.942); SPE1 (0.941); PRO3 (0.936); URA2 (0.933); LYS1 (0.926)
Homologues (species, bitscore): NAGS (Homo sapiens, 135.2); Nags (Mus musculus, 127.9); LOC557716 (Danio rerio, 112.5); nags (Xenopus tropicalis, 124.8); AT2G19940 (Arabidopsis thaliana, 132.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:289189-291780:+ | gene-YER069W_AKU4011 | rna-NM_001178960.1_AKU4011 | cds-NP_010992.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:134000-136591:- | gene-YER069W_BG1 | rna-NM_001178960.1_BG1 | cds-NP_010992.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:298786-301377:+ | gene-YER069W_Bruggeman | rna-NM_001178960.1_Bruggeman | cds-NP_010992.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:292638-295229:+ | gene-YER069W_CAT1 | rna-NM_001178960.1_CAT1 | cds-NP_010992.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:289039-291630:+ | gene-YER069W_CBS1585 | rna-NM_001178960.1_CBS1585 | cds-NP_010992.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:291195-293786:+ | gene-YER069W_CBS436 | rna-NM_001178960.1_CBS436 | cds-NP_010992.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:288510-291101:+ | gene-YER069W_CBS6412 | rna-NM_001178960.1_CBS6412 | cds-NP_010992.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:294521-297112:+ | gene-YER069W_CBS6413 | rna-NM_001178960.1_CBS6413 | cds-NP_010992.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:293236-295827:+ | gene-YER069W_CENPK1137D | rna-NM_001178960.1_CENPK1137D | cds-NP_010992.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:289525-292116:+ | gene-YER069W_EthanolRed | rna-NM_001178960.1_EthanolRed | cds-NP_010992.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:289977-292568:+ | gene-YER069W_FaliES1 | rna-NM_001178960.1_FaliES1 | cds-NP_010992.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000153.1:5041-7632:+ | gene-YER069W_JAY291 | rna-NM_001178960.1_JAY291 | cds-NP_010992.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:294184-296775:+ | gene-YER069W_MUCL30387 | rna-NM_001178960.1_MUCL30387 | cds-NP_010992.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:289854-292445:+ | gene-YER069W_MUCL30388 | rna-NM_001178960.1_MUCL30388 | cds-NP_010992.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:288075-290666:+ | gene-YER069W_MUCL39482 | rna-NM_001178960.1_MUCL39482 | cds-NP_010992.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:295316-297907:+ | gene-YER069W_MUCL42920 | rna-NM_001178960.1_MUCL42920 | cds-NP_010992.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:295409-298000:+ | gene-YER069W_NCIM3186 | rna-NM_001178960.1_NCIM3186 | cds-NP_010992.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:293142-295733:+ | gene-YER069W_NCYC1407 | rna-NM_001178960.1_NCYC1407 | cds-NP_010992.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:303792-306383:+ | gene-YER069W_PE2H3 | rna-NM_001178960.1_PE2H3 | cds-NP_010992.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:293733-296324:+ | gene-YER069W_PE2H4 | rna-NM_001178960.1_PE2H4 | cds-NP_010992.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:295410-298001:+ | gene-YER069W_S288C | rna-NM_001178960.1_S288C | cds-NP_010992.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:5052-7643:+ | gene-YER069W_SA1 | rna-NM_001178960.1_SA1 | cds-NP_010992.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:290773-293364:+ | gene-YER069W_ThermosaccDry | rna-NM_001178960.1_ThermosaccDry | cds-NP_010992.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:291471-294062:+ | gene-YER069W_VR1 | rna-NM_001178960.1_VR1 | cds-NP_010992.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:287941-290532:+ | gene-YER069W_ZTW1 | rna-NM_001178960.1_ZTW1 | cds-NP_010992.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:291317-293908:+ | gene-YER069W_Sparadoxus | rna-NM_001178960.1_Sparadoxus | cds-NP_010992.1_Sparadoxus | 90.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |