Gene name: APN1
Reference locus (S288C): YKL114C
Gene biotype: protein_coding
Description: DNA-(apurinic or apyrimidinic site) lyase 1; Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity; Belongs to the AP endonuclease 2 family
Top 10 interactors (score): APN2 (0.999); NTG1 (0.996); NTG2 (0.996); UNG1 (0.993); RAD14 (0.976); RAD10 (0.968); OGG1 (0.967); REV3 (0.967); RAD27 (0.963); RAD1 (0.958); DUT1 (0.951); MAG1 (0.951); TDP1 (0.94); RAD52 (0.902); REV1 (0.901); RAD18 (0.894); RAD2 (0.891); HAT1 (0.877); CDC9 (0.857); MSH2 (0.844)
Homologues (species, bitscore): LOC558198 (Danio rerio, 244.6); ENSXETP00000063870 (Xenopus tropicalis, 225.3); apn-1 (Caenorhabditis elegans, 238.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:209929-211032:- | gene-YKL114C_AKU4011 | rna-NM_001179680.1_AKU4011 | cds-NP_012808.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:187053-188156:- | gene-YKL114C_BG1 | rna-NM_001179680.1_BG1 | cds-NP_012808.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:227844-228947:- | gene-YKL114C_Bruggeman | rna-NM_001179680.1_Bruggeman | cds-NP_012808.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:222899-224002:- | gene-YKL114C_CAT1 | rna-NM_001179680.1_CAT1 | cds-NP_012808.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:222161-223264:- | gene-YKL114C_CBS1585 | rna-NM_001179680.1_CBS1585 | cds-NP_012808.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:220749-221852:- | gene-YKL114C_CBS436 | rna-NM_001179680.1_CBS436 | cds-NP_012808.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:206791-207894:- | gene-YKL114C_CBS6412 | rna-NM_001179680.1_CBS6412 | cds-NP_012808.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:222625-223728:- | gene-YKL114C_CBS6413 | rna-NM_001179680.1_CBS6413 | cds-NP_012808.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:222994-224097:- | gene-YKL114C_CENPK1137D | rna-NM_001179680.1_CENPK1137D | cds-NP_012808.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:220606-221709:- | gene-YKL114C_EthanolRed | rna-NM_001179680.1_EthanolRed | cds-NP_012808.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:221419-222522:- | gene-YKL114C_FaliES1 | rna-NM_001179680.1_FaliES1 | cds-NP_012808.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000357.1:43767-44870:- | gene-YKL114C_JAY291 | rna-NM_001179680.1_JAY291 | cds-NP_012808.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:229656-230759:- | gene-YKL114C_MUCL30387 | rna-NM_001179680.1_MUCL30387 | cds-NP_012808.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:224035-225138:- | gene-YKL114C_MUCL30388 | rna-NM_001179680.1_MUCL30388 | cds-NP_012808.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:221956-223059:- | gene-YKL114C_MUCL39482 | rna-NM_001179680.1_MUCL39482 | cds-NP_012808.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:226331-227434:- | gene-YKL114C_MUCL42920 | rna-NM_001179680.1_MUCL42920 | cds-NP_012808.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:223341-224444:- | gene-YKL114C_NCIM3186 | rna-NM_001179680.1_NCIM3186 | cds-NP_012808.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:222137-223240:- | gene-YKL114C_NCYC1407 | rna-NM_001179680.1_NCYC1407 | cds-NP_012808.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:229239-230342:- | gene-YKL114C_PE2H3 | rna-NM_001179680.1_PE2H3 | cds-NP_012808.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:225519-226622:- | gene-YKL114C_PE2H4 | rna-NM_001179680.1_PE2H4 | cds-NP_012808.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:223352-224455:- | gene-YKL114C_S288C | rna-NM_001179680.1_S288C | cds-NP_012808.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:139478-140581:- | gene-YKL114C_SA1 | rna-NM_001179680.1_SA1 | cds-NP_012808.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:222119-223222:- | gene-YKL114C_ThermosaccDry | rna-NM_001179680.1_ThermosaccDry | cds-NP_012808.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:221490-222593:- | gene-YKL114C_VR1 | rna-NM_001179680.1_VR1 | cds-NP_012808.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:220693-221796:- | gene-YKL114C_ZTW1 | rna-NM_001179680.1_ZTW1 | cds-NP_012808.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:237670-238773:- | gene-YKL114C_Sparadoxus | rna-NM_001179680.1_Sparadoxus | cds-NP_012808.1_Sparadoxus | 90.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |