Gene name: APM4
Reference locus (S288C): YOL062C
Gene biotype: protein_coding
Description: Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals; Belongs to the adaptor complexes medium subunit family
Top 10 interactors (score): APS2 (0.999); APL3 (0.999); APL1 (0.999); APL2 (0.998); EDE1 (0.996); CHC1 (0.993); APL4 (0.974); YAP1801 (0.969); YAP1802 (0.968); APL5 (0.967); SEC16 (0.962); END3 (0.962); CLC1 (0.957); APS1 (0.956); APL6 (0.946); APS3 (0.945); PRK1 (0.933); ENT3 (0.931); ENT5 (0.931); VPS1 (0.93)
Homologues (species, bitscore): AP2M1 (Homo sapiens, 271.6); Ap2m1 (Mus musculus, 271.6); ap2m1a (Danio rerio, 271.9); ap2m1 (Xenopus tropicalis, 271.6); AP-2mu (Drosophila melanogaster, 275.0); dpy-23 (Caenorhabditis elegans, 286.6); AT5G46630 (Arabidopsis thaliana, 225.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:194172-195647:- | gene-YOL062C_AKU4011 | rna-NM_001183317.1_AKU4011 | cds-NP_014579.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000152.1:10042-11517:- | gene-YOL062C_BG1 | rna-NM_001183317.1_BG1 | cds-NP_014579.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:195841-197316:- | gene-YOL062C_Bruggeman | rna-NM_001183317.1_Bruggeman | cds-NP_014579.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:195357-196832:- | gene-YOL062C_CAT1 | rna-NM_001183317.1_CAT1 | cds-NP_014579.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:188563-190038:- | gene-YOL062C_CBS1585 | rna-NM_001183317.1_CBS1585 | cds-NP_014579.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:193726-195201:- | gene-YOL062C_CBS436 | rna-NM_001183317.1_CBS436 | cds-NP_014579.1_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:188492-189967:- | gene-YOL062C_CBS6412 | rna-NM_001183317.1_CBS6412 | cds-NP_014579.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:195428-196903:- | gene-YOL062C_CBS6413 | rna-NM_001183317.1_CBS6413 | cds-NP_014579.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:210268-211743:- | gene-YOL062C_CENPK1137D | rna-NM_001183317.1_CENPK1137D | cds-NP_014579.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:191272-192747:- | gene-YOL062C_EthanolRed | rna-NM_001183317.1_EthanolRed | cds-NP_014579.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:193815-195290:- | gene-YOL062C_FaliES1 | rna-NM_001183317.1_FaliES1 | cds-NP_014579.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000018.1:70267-71742:+ | gene-YOL062C_JAY291 | rna-NM_001183317.1_JAY291 | cds-NP_014579.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:199606-201081:- | gene-YOL062C_MUCL30387 | rna-NM_001183317.1_MUCL30387 | cds-NP_014579.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:203290-204765:- | gene-YOL062C_MUCL30388 | rna-NM_001183317.1_MUCL30388 | cds-NP_014579.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:196483-197958:- | gene-YOL062C_MUCL39482 | rna-NM_001183317.1_MUCL39482 | cds-NP_014579.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:211963-213438:- | gene-YOL062C_MUCL42920 | rna-NM_001183317.1_MUCL42920 | cds-NP_014579.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:210409-211884:- | gene-YOL062C_NCIM3186 | rna-NM_001183317.1_NCIM3186 | cds-NP_014579.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:203100-204575:- | gene-YOL062C_NCYC1407 | rna-NM_001183317.1_NCYC1407 | cds-NP_014579.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:186108-187583:- | gene-YOL062C_PE2H3 | rna-NM_001183317.1_PE2H3 | cds-NP_014579.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:197098-198573:- | gene-YOL062C_PE2H4 | rna-NM_001183317.1_PE2H4 | cds-NP_014579.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:210520-211995:- | gene-YOL062C_S288C | rna-NM_001183317.1_S288C | cds-NP_014579.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:178456-179931:- | gene-YOL062C_SA1 | rna-NM_001183317.1_SA1 | cds-NP_014579.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:192823-194298:- | gene-YOL062C_ThermosaccDry | rna-NM_001183317.1_ThermosaccDry | cds-NP_014579.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:193588-195063:- | gene-YOL062C_VR1 | rna-NM_001183317.1_VR1 | cds-NP_014579.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:192466-193941:- | gene-YOL062C_ZTW1 | rna-NM_001183317.1_ZTW1 | cds-NP_014579.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:195988-197463:- | gene-YOL062C_Sparadoxus | rna-NM_001183317.1_Sparadoxus | cds-NP_014579.1_Sparadoxus | 92.1 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |