Gene name: APE4
Reference locus (S288C): YHR113W
Gene biotype: protein_coding
Description: Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family
Top 10 interactors (score): FRA1 (0.982); AMS1 (0.979); YJL068C (0.969); ATG19 (0.969); ADO1 (0.964); PRM15 (0.963); ADE12 (0.962); RKI1 (0.962); ADH4 (0.962); SAH1 (0.961); ICP55 (0.922); COQ3 (0.921); ATG8 (0.834); COQ2 (0.829); APE2 (0.801); YPL109C (0.768); ATG34 (0.767); ATG11 (0.763); APE1 (0.75); ATG32 (0.697)
Homologues (species, bitscore): DNPEP (Homo sapiens, 416.8); Dnpep (Mus musculus, 417.5); dnpep (Danio rerio, 407.5); dnpep (Xenopus tropicalis, 407.5); dnpp-1 (Caenorhabditis elegans, 394.4); AT5G60160 (Arabidopsis thaliana, 397.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:323257-324729:+ | gene-YHR113W_AKU4011 | rna-NM_001179243.1_AKU4011 | cds-NP_011981.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000141.1:193184-194656:- | gene-YHR113W_BG1 | rna-NM_001179243.1_BG1 | cds-NP_011981.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:330547-332019:+ | gene-YHR113W_Bruggeman | rna-NM_001179243.1_Bruggeman | cds-NP_011981.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:325688-327160:+ | gene-YHR113W_CAT1 | rna-NM_001179243.1_CAT1 | cds-NP_011981.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:322281-323753:+ | gene-YHR113W_CBS1585 | rna-NM_001179243.1_CBS1585 | cds-NP_011981.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:319631-321103:+ | gene-YHR113W_CBS436 | rna-NM_001179243.1_CBS436 | cds-NP_011981.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:324091-325563:+ | gene-YHR113W_CBS6412 | rna-NM_001179243.1_CBS6412 | cds-NP_011981.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:323308-324780:+ | gene-YHR113W_CBS6413 | rna-NM_001179243.1_CBS6413 | cds-NP_011981.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:329504-330976:+ | gene-YHR113W_CENPK1137D | rna-NM_001179243.1_CENPK1137D | cds-NP_011981.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:382166-383638:+ | gene-YHR113W_EthanolRed | rna-NM_001179243.1_EthanolRed | cds-NP_011981.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:323654-325126:+ | gene-YHR113W_FaliES1 | rna-NM_001179243.1_FaliES1 | cds-NP_011981.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000045.1:44228-45700:+ | gene-YHR113W_JAY291 | rna-NM_001179243.1_JAY291 | cds-NP_011981.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:330275-331747:+ | gene-YHR113W_MUCL30387 | rna-NM_001179243.1_MUCL30387 | cds-NP_011981.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:329925-331397:+ | gene-YHR113W_MUCL30388 | rna-NM_001179243.1_MUCL30388 | cds-NP_011981.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:322622-324094:+ | gene-YHR113W_MUCL39482 | rna-NM_001179243.1_MUCL39482 | cds-NP_011981.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:328863-330335:+ | gene-YHR113W_MUCL42920 | rna-NM_001179243.1_MUCL42920 | cds-NP_011981.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:336219-337691:+ | gene-YHR113W_NCIM3186 | rna-NM_001179243.1_NCIM3186 | cds-NP_011981.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:324830-326302:+ | gene-YHR113W_NCYC1407 | rna-NM_001179243.1_NCYC1407 | cds-NP_011981.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:324264-325736:+ | gene-YHR113W_PE2H3 | rna-NM_001179243.1_PE2H3 | cds-NP_011981.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:331691-333163:+ | gene-YHR113W_PE2H4 | rna-NM_001179243.1_PE2H4 | cds-NP_011981.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:336337-337809:+ | gene-YHR113W_S288C | rna-NM_001179243.1_S288C | cds-NP_011981.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000014.1:21171-22643:- | gene-YHR113W_SA1 | rna-NM_001179243.1_SA1 | cds-NP_011981.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:324737-326209:+ | gene-YHR113W_ThermosaccDry | rna-NM_001179243.1_ThermosaccDry | cds-NP_011981.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:332352-333824:+ | gene-YHR113W_VR1 | rna-NM_001179243.1_VR1 | cds-NP_011981.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:315772-317244:+ | gene-YHR113W_ZTW1 | rna-NM_001179243.1_ZTW1 | cds-NP_011981.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:321428-322900:+ | gene-YHR113W_Sparadoxus | rna-NM_001179243.1_Sparadoxus | cds-NP_011981.1_Sparadoxus | 88.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |