Gene name: APC1
Reference locus (S288C): YNL172W
Gene biotype: protein_coding
Description: Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress; Belongs to the APC1 family
Top 10 interactors (score): MND2 (0.999); APC4 (0.999); APC9 (0.999); CDC27 (0.999); APC5 (0.999); CDC26 (0.999); CDC16 (0.999); CDC23 (0.999); SWM1 (0.999); CDH1 (0.999); APC2 (0.999); APC11 (0.999); DOC1 (0.999); CDC20 (0.998); MAD3 (0.996); MAD2 (0.995); AMA1 (0.991); BUB1 (0.981); CDC4 (0.931); BUB3 (0.913)
Homologues (species, bitscore): ANAPC1 (Homo sapiens, 263.8); Anapc1 (Mus musculus, 256.9); anapc1 (Danio rerio, 250.4); anapc1 (Xenopus tropicalis, 261.9); shtd (Drosophila melanogaster, 224.2); mat-2 (Caenorhabditis elegans, 145.6); EMB2771 (Arabidopsis thaliana, 203.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:304361-309604:+ | gene-YNL172W_AKU4011 | rna-NM_001183010.4_AKU4011 | cds-NP_014227.4_AKU4011 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:208330-213573:+ | gene-YNL172W_BG1 | rna-NM_001183010.4_BG1 | cds-NP_014227.4_BG1 | 99.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:314422-319665:+ | gene-YNL172W_Bruggeman | rna-NM_001183010.4_Bruggeman | cds-NP_014227.4_Bruggeman | 99.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:357299-362542:+ | gene-YNL172W_CAT1 | rna-NM_001183010.4_CAT1 | cds-NP_014227.4_CAT1 | 99.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:305013-310256:+ | gene-YNL172W_CBS1585 | rna-NM_001183010.4_CBS1585 | cds-NP_014227.4_CBS1585 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:373337-378580:+ | gene-YNL172W_CBS436 | rna-NM_001183010.4_CBS436 | cds-NP_014227.4_CBS436 | 99.9 | 99.9 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:300418-305661:+ | gene-YNL172W_CBS6412 | rna-NM_001183010.4_CBS6412 | cds-NP_014227.4_CBS6412 | 99.4 | 99.9 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:301446-306689:+ | gene-YNL172W_CBS6413 | rna-NM_001183010.4_CBS6413 | cds-NP_014227.4_CBS6413 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:304452-309695:+ | gene-YNL172W_CENPK1137D | rna-NM_001183010.4_CENPK1137D | cds-NP_014227.4_CENPK1137D | 99.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:301334-306577:+ | gene-YNL172W_EthanolRed | rna-NM_001183010.4_EthanolRed | cds-NP_014227.4_EthanolRed | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:297247-302490:+ | gene-YNL172W_FaliES1 | rna-NM_001183010.4_FaliES1 | cds-NP_014227.4_FaliES1 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000260.1:16005-21248:- | gene-YNL172W_JAY291 | rna-NM_001183010.4_JAY291 | cds-NP_014227.4_JAY291 | 99.8 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:310237-315480:+ | gene-YNL172W_MUCL30387 | rna-NM_001183010.4_MUCL30387 | cds-NP_014227.4_MUCL30387 | 99.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:344791-350034:+ | gene-YNL172W_MUCL30388 | rna-NM_001183010.4_MUCL30388 | cds-NP_014227.4_MUCL30388 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:302252-307495:+ | gene-YNL172W_MUCL39482 | rna-NM_001183010.4_MUCL39482 | cds-NP_014227.4_MUCL39482 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:304658-309901:+ | gene-YNL172W_MUCL42920 | rna-NM_001183010.4_MUCL42920 | cds-NP_014227.4_MUCL42920 | 99.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:310605-315851:+ | gene-YNL172W_NCIM3186 | rna-NM_001183010.4_NCIM3186 | cds-NP_014227.4_NCIM3186 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:304346-309589:+ | gene-YNL172W_NCYC1407 | rna-NM_001183010.4_NCYC1407 | cds-NP_014227.4_NCYC1407 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:301311-306554:+ | gene-YNL172W_PE2H3 | rna-NM_001183010.4_PE2H3 | cds-NP_014227.4_PE2H3 | 99.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:300699-305942:+ | gene-YNL172W_PE2H4 | rna-NM_001183010.4_PE2H4 | cds-NP_014227.4_PE2H4 | 99.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:310636-315882:+ | gene-YNL172W_S288C | rna-NM_001183010.4_S288C | cds-NP_014227.4_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000018.1:97694-102937:- | gene-YNL172W_SA1 | rna-NM_001183010.4_SA1 | cds-NP_014227.4_SA1 | 99.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:298104-303347:+ | gene-YNL172W_ThermosaccDry | rna-NM_001183010.4_ThermosaccDry | cds-NP_014227.4_ThermosaccDry | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:316631-321874:+ | gene-YNL172W_VR1 | rna-NM_001183010.4_VR1 | cds-NP_014227.4_VR1 | 99.8 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:207929-213172:+ | gene-YNL172W_ZTW1 | rna-NM_001183010.4_ZTW1 | cds-NP_014227.4_ZTW1 | 99.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:308679-313922:+ | gene-YNL172W_Sparadoxus | rna-NM_001183010.4_Sparadoxus | cds-NP_014227.4_Sparadoxus | 88.3 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |