Gene name: AOS1
Reference locus (S288C): YPR180W
Gene biotype: protein_coding
Description: DNA damage tolerance protein RHC31; Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; relocalizes to the cytosol in response to hypoxia
Top 10 interactors (score): UBC9 (0.999); SMT3 (0.999); UBA2 (0.999); ULP1 (0.985); NFI1 (0.981); MMS21 (0.976); ULP2 (0.972); SIZ1 (0.967); UBC12 (0.943); POL30 (0.93); URM1 (0.919); HRT1 (0.918); CDC53 (0.91); DUT1 (0.907); BUB3 (0.901); ARP4 (0.899); SKP1 (0.891); SMB1 (0.887); PRP19 (0.881); ARP7 (0.875)
Homologues (species, bitscore): SAE1 (Homo sapiens, 188.0); Sae1 (Mus musculus, 182.6); sae1 (Danio rerio, 159.5); sae1 (Xenopus tropicalis, 167.5); Aos1 (Drosophila melanogaster, 152.1); aos-1 (Caenorhabditis elegans, 119.8); SAE1B-1 (Arabidopsis thaliana, 117.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:850241-851284:+ | gene-YPR180W_AKU4011 | rna-NM_001184277.1_AKU4011 | cds-NP_015506.1_AKU4011 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:46427-47470:- | gene-YPR180W_BG1 | rna-NM_001184277.1_BG1 | cds-NP_015506.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:931524-932567:+ | gene-YPR180W_Bruggeman | rna-NM_001184277.1_Bruggeman | cds-NP_015506.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:973580-974623:+ | gene-YPR180W_CAT1 | rna-NM_001184277.1_CAT1 | cds-NP_015506.1_CAT1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:855043-856086:+ | gene-YPR180W_CBS1585 | rna-NM_001184277.1_CBS1585 | cds-NP_015506.1_CBS1585 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:868588-869631:+ | gene-YPR180W_CBS436 | rna-NM_001184277.1_CBS436 | cds-NP_015506.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:856827-857870:+ | gene-YPR180W_CBS6412 | rna-NM_001184277.1_CBS6412 | cds-NP_015506.1_CBS6412 | 98.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:851971-853014:+ | gene-YPR180W_CBS6413 | rna-NM_001184277.1_CBS6413 | cds-NP_015506.1_CBS6413 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:896046-897089:+ | gene-YPR180W_CENPK1137D | rna-NM_001184277.1_CENPK1137D | cds-NP_015506.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:1172002-1173045:+ | gene-YPR180W_EthanolRed | rna-NM_001184277.1_EthanolRed | cds-NP_015506.1_EthanolRed | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:852075-853118:+ | gene-YPR180W_FaliES1 | rna-NM_001184277.1_FaliES1 | cds-NP_015506.1_FaliES1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000081.1:39371-40414:+ | gene-YPR180W_JAY291 | rna-NM_001184277.1_JAY291 | cds-NP_015506.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:898770-899813:+ | gene-YPR180W_MUCL30387 | rna-NM_001184277.1_MUCL30387 | cds-NP_015506.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:872899-873942:+ | gene-YPR180W_MUCL30388 | rna-NM_001184277.1_MUCL30388 | cds-NP_015506.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:847243-848286:+ | gene-YPR180W_MUCL39482 | rna-NM_001184277.1_MUCL39482 | cds-NP_015506.1_MUCL39482 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:911712-912755:+ | gene-YPR180W_MUCL42920 | rna-NM_001184277.1_MUCL42920 | cds-NP_015506.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:895944-896987:+ | gene-YPR180W_NCIM3186 | rna-NM_001184277.1_NCIM3186 | cds-NP_015506.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:855604-856647:+ | gene-YPR180W_NCYC1407 | rna-NM_001184277.1_NCYC1407 | cds-NP_015506.1_NCYC1407 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:867895-868938:+ | gene-YPR180W_PE2H3 | rna-NM_001184277.1_PE2H3 | cds-NP_015506.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:867543-868586:+ | gene-YPR180W_PE2H4 | rna-NM_001184277.1_PE2H4 | cds-NP_015506.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:895961-897004:+ | gene-YPR180W_S288C | rna-NM_001184277.1_S288C | cds-NP_015506.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000060.1:28808-29851:- | gene-YPR180W_SA1 | rna-NM_001184277.1_SA1 | cds-NP_015506.1_SA1 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:851763-852806:+ | gene-YPR180W_ThermosaccDry | rna-NM_001184277.1_ThermosaccDry | cds-NP_015506.1_ThermosaccDry | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:879550-880593:+ | gene-YPR180W_VR1 | rna-NM_001184277.1_VR1 | cds-NP_015506.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:854312-855355:+ | gene-YPR180W_ZTW1 | rna-NM_001184277.1_ZTW1 | cds-NP_015506.1_ZTW1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:856379-857422:+ | gene-YPR180W_Sparadoxus | rna-NM_001184277.1_Sparadoxus | cds-NP_015506.1_Sparadoxus | 89.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |