Gene name: ALT1
Reference locus (S288C): YLR089C
Gene biotype: protein_coding
Description: Probable alanine aminotransferase, mitochondrial; Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily
Top 10 interactors (score): FUM1 (0.984); AGX1 (0.977); GDH2 (0.971); GDH3 (0.969); ALT2 (0.954); GDH1 (0.945); AAT2 (0.94); AAT1 (0.939); ARG7 (0.927); TPI1 (0.921); ARG2 (0.909); YFR006W (0.887); IDP1 (0.883); UGA1 (0.881); ACO1 (0.852); KGD1 (0.845); IDP2 (0.834); IDP3 (0.834); ECM38 (0.825); IDH1 (0.815)
Homologues (species, bitscore): GPT2 (Homo sapiens, 425.2); Gpt2 (Mus musculus, 415.2); gpt2l (Danio rerio, 407.5); gpt (Xenopus tropicalis, 414.8); CG1640 (Drosophila melanogaster, 379.0); C32F10.8 (Caenorhabditis elegans, 382.9); ALAAT2 (Arabidopsis thaliana, 432.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:300709-302487:- | gene-YLR089C_AKU4011 | rna-NM_001181976.1_AKU4011 | cds-NP_013190.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:263879-265657:- | gene-YLR089C_BG1 | rna-NM_001181976.1_BG1 | cds-NP_013190.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:310617-312395:- | gene-YLR089C_Bruggeman | rna-NM_001181976.1_Bruggeman | cds-NP_013190.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:310936-312714:- | gene-YLR089C_CAT1 | rna-NM_001181976.1_CAT1 | cds-NP_013190.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:307823-309601:- | gene-YLR089C_CBS1585 | rna-NM_001181976.1_CBS1585 | cds-NP_013190.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:298444-300222:- | gene-YLR089C_CBS436 | rna-NM_001181976.1_CBS436 | cds-NP_013190.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:306264-308042:- | gene-YLR089C_CBS6412 | rna-NM_001181976.1_CBS6412 | cds-NP_013190.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:308095-309873:- | gene-YLR089C_CBS6413 | rna-NM_001181976.1_CBS6413 | cds-NP_013190.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:303244-305022:- | gene-YLR089C_CENPK1137D | rna-NM_001181976.1_CENPK1137D | cds-NP_013190.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:300228-302006:- | gene-YLR089C_EthanolRed | rna-NM_001181976.1_EthanolRed | cds-NP_013190.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:300104-301882:- | gene-YLR089C_FaliES1 | rna-NM_001181976.1_FaliES1 | cds-NP_013190.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000129.1:75044-76822:- | gene-YLR089C_JAY291 | rna-NM_001181976.1_JAY291 | cds-NP_013190.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:307979-309757:- | gene-YLR089C_MUCL30387 | rna-NM_001181976.1_MUCL30387 | cds-NP_013190.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:315629-317407:- | gene-YLR089C_MUCL30388 | rna-NM_001181976.1_MUCL30388 | cds-NP_013190.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:308341-310119:- | gene-YLR089C_MUCL39482 | rna-NM_001181976.1_MUCL39482 | cds-NP_013190.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:308264-310042:- | gene-YLR089C_MUCL42920 | rna-NM_001181976.1_MUCL42920 | cds-NP_013190.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:318211-319989:- | gene-YLR089C_NCIM3186 | rna-NM_001181976.1_NCIM3186 | cds-NP_013190.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:300412-302190:- | gene-YLR089C_NCYC1407 | rna-NM_001181976.1_NCYC1407 | cds-NP_013190.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:306277-308055:- | gene-YLR089C_PE2H3 | rna-NM_001181976.1_PE2H3 | cds-NP_013190.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:306018-307796:- | gene-YLR089C_PE2H4 | rna-NM_001181976.1_PE2H4 | cds-NP_013190.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:318237-320015:- | gene-YLR089C_S288C | rna-NM_001181976.1_S288C | cds-NP_013190.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000033.1:54103-55881:+ | gene-YLR089C_SA1 | rna-NM_001181976.1_SA1 | cds-NP_013190.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:300280-302058:- | gene-YLR089C_ThermosaccDry | rna-NM_001181976.1_ThermosaccDry | cds-NP_013190.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:314465-316243:- | gene-YLR089C_VR1 | rna-NM_001181976.1_VR1 | cds-NP_013190.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:299661-301439:- | gene-YLR089C_ZTW1 | rna-NM_001181976.1_ZTW1 | cds-NP_013190.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:308507-310285:- | gene-YLR089C_Sparadoxus | rna-NM_001181976.1_Sparadoxus | cds-NP_013190.1_Sparadoxus | 93.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |