Gene name: ALK2
Reference locus (S288C): YBL009W
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase Haspin homolog ALK2; Protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of cell polarity factors in mitosis, proper localization of formins and polarity factors, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
Top 10 interactors (score): PDS5 (0.77); IPL1 (0.681); PAU7 (0.678); MAD3 (0.668); BUB1 (0.668); PEP5 (0.647); YCG1 (0.614); RPL32 (0.613); RPS15 (0.613); MPS1 (0.583); IRS4 (0.564); ICS2 (0.53); DDP1 (0.53); SRL1 (0.524); TOS2 (0.523); TOS4 (0.508); WWM1 (0.499); PAU5 (0.489); LDB7 (0.487); YOR012W (0.483)
Homologues (species, bitscore): GSG2 (Homo sapiens, 53.9); Gsg2 (Mus musculus, 54.7); GSG2 (Danio rerio, 71.2); Haspin (Drosophila melanogaster, 69.7); C01H6.9 (Caenorhabditis elegans, 58.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:201298-203328:+ | gene-YBL009W_AKU4011 | rna-NM_001178249.1_AKU4011 | cds-NP_009544.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:191621-193651:+ | gene-YBL009W_BG1 | rna-NM_001178249.1_BG1 | cds-NP_009544.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:201955-203985:+ | gene-YBL009W_Bruggeman | rna-NM_001178249.1_Bruggeman | cds-NP_009544.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:204480-206510:+ | gene-YBL009W_CAT1 | rna-NM_001178249.1_CAT1 | cds-NP_009544.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:193586-195616:+ | gene-YBL009W_CBS1585 | rna-NM_001178249.1_CBS1585 | cds-NP_009544.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:201794-203824:+ | gene-YBL009W_CBS436 | rna-NM_001178249.1_CBS436 | cds-NP_009544.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:292086-294116:+ | gene-YBL009W_CBS6412 | rna-NM_001178249.1_CBS6412 | cds-NP_009544.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:198907-200937:+ | gene-YBL009W_CBS6413 | rna-NM_001178249.1_CBS6413 | cds-NP_009544.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:200958-202988:+ | gene-YBL009W_CENPK1137D | rna-NM_001178249.1_CENPK1137D | cds-NP_009544.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:328507-330558:+ | gene-YBL009W_EthanolRed | rna-NM_001178249.1_EthanolRed | cds-NP_009544.1_EthanolRed | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:216108-218159:+ | gene-YBL009W_FaliES1 | rna-NM_001178249.1_FaliES1 | cds-NP_009544.1_FaliES1 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000048.1:78960-80990:- | gene-YBL009W_JAY291 | rna-NM_001178249.1_JAY291 | cds-NP_009544.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:202556-204586:+ | gene-YBL009W_MUCL30387 | rna-NM_001178249.1_MUCL30387 | cds-NP_009544.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:202541-204571:+ | gene-YBL009W_MUCL30388 | rna-NM_001178249.1_MUCL30388 | cds-NP_009544.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:193522-195552:+ | gene-YBL009W_MUCL39482 | rna-NM_001178249.1_MUCL39482 | cds-NP_009544.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:200962-202992:+ | gene-YBL009W_MUCL42920 | rna-NM_001178249.1_MUCL42920 | cds-NP_009544.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:206991-209021:+ | gene-YBL009W_NCIM3186 | rna-NM_001178249.1_NCIM3186 | cds-NP_009544.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:194698-196728:+ | gene-YBL009W_NCYC1407 | rna-NM_001178249.1_NCYC1407 | cds-NP_009544.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:206868-208898:+ | gene-YBL009W_PE2H3 | rna-NM_001178249.1_PE2H3 | cds-NP_009544.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:204512-206542:+ | gene-YBL009W_PE2H4 | rna-NM_001178249.1_PE2H4 | cds-NP_009544.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:207194-209224:+ | gene-YBL009W_S288C | rna-NM_001178249.1_S288C | cds-NP_009544.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000037.1:87643-89673:- | gene-YBL009W_SA1 | rna-NM_001178249.1_SA1 | cds-NP_009544.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:216063-218114:+ | gene-YBL009W_ThermosaccDry | rna-NM_001178249.1_ThermosaccDry | cds-NP_009544.1_ThermosaccDry | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:198205-200235:+ | gene-YBL009W_VR1 | rna-NM_001178249.1_VR1 | cds-NP_009544.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:192268-194319:+ | gene-YBL009W_ZTW1 | rna-NM_001178249.1_ZTW1 | cds-NP_009544.1_ZTW1 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:227872-229899:+ | gene-YBL009W_Sparadoxus | rna-NM_001178249.1_Sparadoxus | cds-NP_009544.1_Sparadoxus | 87.6 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |