Gene name: ALD4
Reference locus (S288C): YOR374W
Gene biotype: protein_coding
Description: Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; human homolog ALDH2 can complement yeast ald4 mutant
Top 10 interactors (score): GAD1 (0.986); GUT2 (0.984); UGA1 (0.975); ACH1 (0.971); POX1 (0.968); POS5 (0.967); GLK1 (0.964); ACS1 (0.96); ACS2 (0.955); YEF1 (0.954); NDI1 (0.95); HXK1 (0.947); ADH2 (0.94); NDE1 (0.929); PGM2 (0.928); NDE2 (0.927); UTR1 (0.923); AMD2 (0.919); FMS1 (0.914); TDA10 (0.913)
Homologues (species, bitscore): ALDH1B1 (Homo sapiens, 504.6); Aldh2 (Mus musculus, 505.4); aldh2l (Danio rerio, 501.9); aldh2 (Xenopus tropicalis, 511.5); Aldh (Drosophila melanogaster, 476.1); alh-1 (Caenorhabditis elegans, 501.1); ALDH2B7 (Arabidopsis thaliana, 476.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:1026433-1027992:+ | gene-YOR374W_AKU4011 | rna-NM_001183794.1_AKU4011 | cds-NP_015019.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000183.1:33523-35082:- | gene-YOR374W_BG1 | rna-NM_001183794.1_BG1 | cds-NP_015019.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:1011232-1012791:+ | gene-YOR374W_Bruggeman | rna-NM_001183794.1_Bruggeman | cds-NP_015019.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:1011900-1013459:+ | gene-YOR374W_CAT1 | rna-NM_001183794.1_CAT1 | cds-NP_015019.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:1010843-1012402:+ | gene-YOR374W_CBS1585 | rna-NM_001183794.1_CBS1585 | cds-NP_015019.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:1005655-1007214:+ | gene-YOR374W_CBS436 | rna-NM_001183794.1_CBS436 | cds-NP_015019.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:239780-241339:+ | gene-YOR374W_CBS6412 | rna-NM_001183794.1_CBS6412 | cds-NP_015019.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:1015117-1016676:+ | gene-YOR374W_CBS6413 | rna-NM_001183794.1_CBS6413 | cds-NP_015019.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:1039696-1041255:+ | gene-YOR374W_CENPK1137D | rna-NM_001183794.1_CENPK1137D | cds-NP_015019.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:254963-256522:+ | gene-YOR374W_EthanolRed | rna-NM_001183794.1_EthanolRed | cds-NP_015019.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:1007971-1009530:+ | gene-YOR374W_FaliES1 | rna-NM_001183794.1_FaliES1 | cds-NP_015019.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000314.1:2323-3883:+ | gene-YOR374W_JAY291 | rna-NM_001183794.1_JAY291 | cds-NP_015019.1_JAY291 | 99.8 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:1020566-1022125:+ | gene-YOR374W_MUCL30387 | rna-NM_001183794.1_MUCL30387 | cds-NP_015019.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:1028593-1030152:+ | gene-YOR374W_MUCL30388 | rna-NM_001183794.1_MUCL30388 | cds-NP_015019.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:1017363-1018922:+ | gene-YOR374W_MUCL39482 | rna-NM_001183794.1_MUCL39482 | cds-NP_015019.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:1024984-1026543:+ | gene-YOR374W_MUCL42920 | rna-NM_001183794.1_MUCL42920 | cds-NP_015019.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:1039729-1041288:+ | gene-YOR374W_NCIM3186 | rna-NM_001183794.1_NCIM3186 | cds-NP_015019.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:1018383-1019942:+ | gene-YOR374W_NCYC1407 | rna-NM_001183794.1_NCYC1407 | cds-NP_015019.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:1013678-1015237:+ | gene-YOR374W_PE2H3 | rna-NM_001183794.1_PE2H3 | cds-NP_015019.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:1030029-1031588:+ | gene-YOR374W_PE2H4 | rna-NM_001183794.1_PE2H4 | cds-NP_015019.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:1039840-1041399:+ | gene-YOR374W_S288C | rna-NM_001183794.1_S288C | cds-NP_015019.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000016.1:144442-146001:+ | gene-YOR374W_SA1 | rna-NM_001183794.1_SA1 | cds-NP_015019.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:1007153-1008712:+ | gene-YOR374W_ThermosaccDry | rna-NM_001183794.1_ThermosaccDry | cds-NP_015019.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:1068659-1070218:+ | gene-YOR374W_VR1 | rna-NM_001183794.1_VR1 | cds-NP_015019.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:739879-741438:+ | gene-YOR374W_ZTW1 | rna-NM_001183794.1_ZTW1 | cds-NP_015019.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:1013870-1015429:+ | gene-YOR374W_Sparadoxus | rna-NM_001183794.1_Sparadoxus | cds-NP_015019.1_Sparadoxus | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |