Gene name: ALA1
Reference locus (S288C): YOR335C
Gene biotype: protein_coding
Description: Alanine--tRNA ligase, mitochondrial; Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis
Top 10 interactors (score): TYS1 (0.995); GRS1 (0.993); CDC60 (0.988); GLN4 (0.986); YHR020W (0.983); VAS1 (0.982); MES1 (0.982); ILS1 (0.98); DED81 (0.979); HTS1 (0.977); SES1 (0.972); KRS1 (0.969); GUS1 (0.963); HIS4 (0.952); YNL247W (0.946); THS1 (0.936); MSK1 (0.933); NAM2 (0.912); MSY1 (0.907); GRS2 (0.9)
Homologues (species, bitscore): AARS (Homo sapiens, 949.5); Aars (Mus musculus, 945.3); aars (Danio rerio, 929.1); aars (Xenopus tropicalis, 916.8); Aats-ala (Drosophila melanogaster, 928.7); aars-2 (Caenorhabditis elegans, 922.5); ALATS (Arabidopsis thaliana, 927.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:936718-939594:- | gene-YOR335C_AKU4011 | rna-NM_001183755.3_AKU4011 | cds-NP_014980.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000100.1:1733-4609:- | gene-YOR335C_BG1 | rna-NM_001183755.3_BG1 | cds-NP_014980.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:922114-924990:- | gene-YOR335C_Bruggeman | rna-NM_001183755.3_Bruggeman | cds-NP_014980.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:922850-925726:- | gene-YOR335C_CAT1 | rna-NM_001183755.3_CAT1 | cds-NP_014980.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:920548-923424:- | gene-YOR335C_CBS1585 | rna-NM_001183755.3_CBS1585 | cds-NP_014980.3_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:918370-921246:- | gene-YOR335C_CBS436 | rna-NM_001183755.3_CBS436 | cds-NP_014980.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:916256-919132:- | gene-YOR335C_CBS6412 | rna-NM_001183755.3_CBS6412 | cds-NP_014980.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:925395-928271:- | gene-YOR335C_CBS6413 | rna-NM_001183755.3_CBS6413 | cds-NP_014980.3_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:946023-948899:- | gene-YOR335C_CENPK1137D | rna-NM_001183755.3_CENPK1137D | cds-NP_014980.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:912641-915517:- | gene-YOR335C_EthanolRed | rna-NM_001183755.3_EthanolRed | cds-NP_014980.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:918247-921123:- | gene-YOR335C_FaliES1 | rna-NM_001183755.3_FaliES1 | cds-NP_014980.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000078.1:82129-85005:+ | gene-YOR335C_JAY291 | rna-NM_001183755.3_JAY291 | cds-NP_014980.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:926607-929483:- | gene-YOR335C_MUCL30387 | rna-NM_001183755.3_MUCL30387 | cds-NP_014980.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:934371-937247:- | gene-YOR335C_MUCL30388 | rna-NM_001183755.3_MUCL30388 | cds-NP_014980.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:927092-929968:- | gene-YOR335C_MUCL39482 | rna-NM_001183755.3_MUCL39482 | cds-NP_014980.3_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:936548-939424:- | gene-YOR335C_MUCL42920 | rna-NM_001183755.3_MUCL42920 | cds-NP_014980.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:946122-948998:- | gene-YOR335C_NCIM3186 | rna-NM_001183755.3_NCIM3186 | cds-NP_014980.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:928088-930964:- | gene-YOR335C_NCYC1407 | rna-NM_001183755.3_NCYC1407 | cds-NP_014980.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:926334-929210:- | gene-YOR335C_PE2H3 | rna-NM_001183755.3_PE2H3 | cds-NP_014980.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:942686-945562:- | gene-YOR335C_PE2H4 | rna-NM_001183755.3_PE2H4 | cds-NP_014980.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:946233-949109:- | gene-YOR335C_S288C | rna-NM_001183755.3_S288C | cds-NP_014980.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000016.1:56645-59521:- | gene-YOR335C_SA1 | rna-NM_001183755.3_SA1 | cds-NP_014980.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:917435-920311:- | gene-YOR335C_ThermosaccDry | rna-NM_001183755.3_ThermosaccDry | cds-NP_014980.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:980729-983605:- | gene-YOR335C_VR1 | rna-NM_001183755.3_VR1 | cds-NP_014980.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:650317-653193:- | gene-YOR335C_ZTW1 | rna-NM_001183755.3_ZTW1 | cds-NP_014980.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:924701-927577:- | gene-YOR335C_Sparadoxus | rna-NM_001183755.3_Sparadoxus | cds-NP_014980.3_Sparadoxus | 92.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |