AIM25 (YJR100C)


Gene profile

Gene name: AIM25
Reference locus (S288C): YJR100C
Gene biotype: protein_coding

Description: Altered inheritance rate of mitochondria protein 25; Mitochondria protein of unknown function; interacts genetically with TOR1 to regulate chronological lifespan, and the response to both heat shock and oxidative stress; involved in maintaining the integrity of the mitochondrial network; negative regulator of mitophagy flux; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant is viable and displays an elevated frequency of mitochondrial genome loss; similar to murine NOR1

Top 10 interactors (score): CSC1 (0.811); MRPL44 (0.714); SEN54 (0.71); PHM7 (0.691); SLM3 (0.685); PUF3 (0.673); OAR1 (0.645); MRP21 (0.633); MAM33 (0.619); FMP30 (0.617); MTG1 (0.617); ECT1 (0.616); ILM1 (0.613); ATG21 (0.593); RSN1 (0.583); CLD1 (0.572); DRS2 (0.571); PET54 (0.568); KTI11 (0.554); CRD1 (0.535)

Homologues (species, bitscore): PLSCR1 (Homo sapiens, 68.6); mCG_17678 (Mus musculus, 72.4); si:ch73-206p6.1 (Danio rerio, 73.6); plscr2 (Xenopus tropicalis, 73.2); scramb1 (Drosophila melanogaster, 69.3); scrm-8 (Caenorhabditis elegans, 61.6); AT2G04940 (Arabidopsis thaliana, 151.4)

External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser


Comparative analysis of strains

Search table

strain assembly application macro_region gene_coord geneID rnaID protID %id %cov_exon status copyNumber copyID nORFs match_ref_CDS validORF missing_startCodon missing_stopCodon outOfFrame_stopCodon
AKU4011 GCA_001738255.1 Sake Asia CM005304.1:587849-588832:- gene-YJR100C_AKU4011 rna-NM_001181758.3_AKU4011 cds-NP_012634.3_AKU4011 99.8 100.0 Verified 1 1 1 True True False False False
BG1 GCA_001932575.1 Bioethanol South America MSHP01000190.1:18740-19723:+ gene-YJR100C_BG1 rna-NM_001181758.3_BG1 cds-NP_012634.3_BG1 100.0 100.0 Verified 1 1 1 True True False False False
Bruggeman GCA_001738585.1 Bread Not Applicable CM005512.1:603582-604565:- gene-YJR100C_Bruggeman rna-NM_001181758.3_Bruggeman cds-NP_012634.3_Bruggeman 99.8 100.0 Verified 1 1 1 True True False False False
CAT1 GCA_001738705.1 Bioethanol South America CM005528.1:606001-606984:- gene-YJR100C_CAT1 rna-NM_001181758.3_CAT1 cds-NP_012634.3_CAT1 99.7 100.0 Verified 1 1 1 False True False False False
CBS1585 GCA_001738375.1 Sake Asia CM005368.1:599914-600897:- gene-YJR100C_CBS1585 rna-NM_001181758.3_CBS1585 cds-NP_012634.3_CBS1585 99.8 100.0 Verified 1 1 1 True True False False False
CBS436 GCA_001738355.1 Sake Asia CM005352.1:618021-619004:- gene-YJR100C_CBS436 rna-NM_001181758.3_CBS436 cds-NP_012634.3_CBS436 99.8 100.0 Mismatch 1 1 1 False True False False False
CBS6412 GCA_001738345.1 Sake Asia CM005336.1:587061-588044:- gene-YJR100C_CBS6412 rna-NM_001181758.3_CBS6412 cds-NP_012634.3_CBS6412 99.8 100.0 Mismatch 1 1 1 True True False False False
CBS6413 GCA_001738265.1 Sake Asia CM005320.1:589322-590305:- gene-YJR100C_CBS6413 rna-NM_001181758.3_CBS6413 cds-NP_012634.3_CBS6413 99.8 100.0 Verified 1 1 1 True True False False False
CENPK1137D GCA_000269885.1 Laboratory Not Applicable CM001531.1:598667-599650:- gene-YJR100C_CENPK1137D rna-NM_001181758.3_CENPK1137D cds-NP_012634.3_CENPK1137D 99.7 100.0 Verified 1 1 1 False True False False False
EthanolRed GCA_001738615.1 Bioethanol Asia CM005480.1:592266-593249:- gene-YJR100C_EthanolRed rna-NM_001181758.3_EthanolRed cds-NP_012634.3_EthanolRed 99.8 100.0 Verified 1 1 1 True True False False False
FaliES1 GCA_001738715.1 Bioethanol Asia CM005544.1:603732-604715:- gene-YJR100C_FaliES1 rna-NM_001181758.3_FaliES1 cds-NP_012634.3_FaliES1 99.8 100.0 Verified 1 1 1 True True False False False
JAY291 GCA_000182315.2 Bioethanol South America ACFL01000054.1:84702-85685:+ gene-YJR100C_JAY291 rna-NM_001181758.3_JAY291 cds-NP_012634.3_JAY291 99.8 100.0 Verified 1 1 1 True True False False False
MUCL30387 GCA_001738515.1 Bread Europe CM005416.1:601886-602869:- gene-YJR100C_MUCL30387 rna-NM_001181758.3_MUCL30387 cds-NP_012634.3_MUCL30387 100.0 100.0 Verified 1 1 1 True True False False False
MUCL30388 GCA_001738495.1 Bread Europe CM005448.1:599198-600181:- gene-YJR100C_MUCL30388 rna-NM_001181758.3_MUCL30388 cds-NP_012634.3_MUCL30388 99.8 100.0 Verified 1 1 1 True True False False False
MUCL39482 GCA_001738235.1 Sake Asia CM005288.1:593373-594356:- gene-YJR100C_MUCL39482 rna-NM_001181758.3_MUCL39482 cds-NP_012634.3_MUCL39482 99.8 100.0 Verified 1 1 1 True True False False False
MUCL42920 GCA_001738485.1 Bread Europe CM005432.1:597628-598611:- gene-YJR100C_MUCL42920 rna-NM_001181758.3_MUCL42920 cds-NP_012634.3_MUCL42920 99.8 100.0 Verified 1 1 1 True True False False False
NCIM3186 GCA_001029075.1 Bioethanol Asia CP011819.1:616330-617313:- gene-YJR100C_NCIM3186 rna-NM_001181758.3_NCIM3186 cds-NP_012634.3_NCIM3186 99.7 100.0 Verified 1 1 1 True True False False False
NCYC1407 GCA_001738225.1 Sake Asia CM005272.1:590940-591923:- gene-YJR100C_NCYC1407 rna-NM_001181758.3_NCYC1407 cds-NP_012634.3_NCYC1407 100.0 100.0 Verified 1 1 1 True True False False False
PE2H3 GCA_905220325.1 Bioethanol South America HG994149.1:608833-609816:- gene-YJR100C_PE2H3 rna-NM_001181758.3_PE2H3 cds-NP_012634.3_PE2H3 99.8 100.0 Verified 1 1 1 True True False False False
PE2H4 GCA_905220315.1 Bioethanol South America LR999881.1:602522-603505:- gene-YJR100C_PE2H4 rna-NM_001181758.3_PE2H4 cds-NP_012634.3_PE2H4 99.8 100.0 Verified 1 1 1 True True False False False
S288C GCF_000146045.2 Laboratory Not applicable NC_001142.9:616351-617334:- gene-YJR100C_S288C rna-NM_001181758.3_S288C cds-NP_012634.3_S288C 100.0 100.0 Verified 1 1 1 True True False False False
SA1 GCA_004114265.1 Bioethanol South America SDIA01000038.1:74921-75904:- gene-YJR100C_SA1 rna-NM_001181758.3_SA1 cds-NP_012634.3_SA1 100.0 100.0 Verified 1 1 1 True True False False False
ThermosaccDry GCA_001738605.1 Bioethanol Asia CM005496.1:597666-598649:- gene-YJR100C_ThermosaccDry rna-NM_001181758.3_ThermosaccDry cds-NP_012634.3_ThermosaccDry 99.8 100.0 Verified 1 1 1 True True False False False
VR1 GCA_001738595.1 Bioethanol South America CM005464.1:599793-600776:- gene-YJR100C_VR1 rna-NM_001181758.3_VR1 cds-NP_012634.3_VR1 100.0 100.0 Verified 1 1 1 True True False False False
ZTW1 GCA_000308935.1 Bioethanol Asia AMDD01000021.1:577033-578016:- gene-YJR100C_ZTW1 rna-NM_001181758.3_ZTW1 cds-NP_012634.3_ZTW1 99.8 100.0 Verified 1 1 1 True True False False False
Sparadoxus GCF_002079055.1 Not applicable Not applicable NC_047496.1:610521-611504:- gene-YJR100C_Sparadoxus rna-NM_001181758.3_Sparadoxus cds-NP_012634.3_Sparadoxus 87.8 100.0 Verified 1 1 1 False True False False False

Additional files