Gene name: AFT1
Reference locus (S288C): YGL071W
Gene biotype: protein_coding
Description: Iron-regulated transcriptional activator AFT1; Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
Top 10 interactors (score): GRX3 (0.995); GRX4 (0.974); FET3 (0.967); FTR1 (0.932); SIT1 (0.928); TIS11 (0.924); YAP5 (0.907); IML3 (0.897); CBF1 (0.895); FRE1 (0.893); YPT7 (0.872); FET4 (0.868); BOL2 (0.861); CCC1 (0.859); SMF3 (0.857); ARN1 (0.851); AFT2 (0.842); MAC1 (0.838); MRS4 (0.819); YFH1 (0.814)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:375017-377089:+ | gene-YGL071W_AKU4011 | rna-NM_001180936.1_AKU4011 | cds-NP_011444.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:28308-30380:- | gene-YGL071W_BG1 | rna-NM_001180936.1_BG1 | cds-NP_011444.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:377498-379570:+ | gene-YGL071W_Bruggeman | rna-NM_001180936.1_Bruggeman | cds-NP_011444.1_Bruggeman | 99.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:374493-376565:+ | gene-YGL071W_CAT1 | rna-NM_001180936.1_CAT1 | cds-NP_011444.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:378562-380634:+ | gene-YGL071W_CBS1585 | rna-NM_001180936.1_CBS1585 | cds-NP_011444.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:372687-374759:+ | gene-YGL071W_CBS436 | rna-NM_001180936.1_CBS436 | cds-NP_011444.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:362721-364793:+ | gene-YGL071W_CBS6412 | rna-NM_001180936.1_CBS6412 | cds-NP_011444.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:372647-374719:+ | gene-YGL071W_CBS6413 | rna-NM_001180936.1_CBS6413 | cds-NP_011444.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:372199-374271:+ | gene-YGL071W_CENPK1137D | rna-NM_001180936.1_CENPK1137D | cds-NP_011444.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:364089-366161:+ | gene-YGL071W_EthanolRed | rna-NM_001180936.1_EthanolRed | cds-NP_011444.1_EthanolRed | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:366650-368722:+ | gene-YGL071W_FaliES1 | rna-NM_001180936.1_FaliES1 | cds-NP_011444.1_FaliES1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000369.1:52345-54417:+ | gene-YGL071W_JAY291 | rna-NM_001180936.1_JAY291 | cds-NP_011444.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:374694-376766:+ | gene-YGL071W_MUCL30387 | rna-NM_001180936.1_MUCL30387 | cds-NP_011444.1_MUCL30387 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:377460-379532:+ | gene-YGL071W_MUCL30388 | rna-NM_001180936.1_MUCL30388 | cds-NP_011444.1_MUCL30388 | 99.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:374870-376942:+ | gene-YGL071W_MUCL39482 | rna-NM_001180936.1_MUCL39482 | cds-NP_011444.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:197166-199238:- | gene-YGL071W_MUCL42920 | rna-NM_001180936.1_MUCL42920 | cds-NP_011444.1_MUCL42920 | 99.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:372012-374084:+ | gene-YGL071W_NCIM3186 | rna-NM_001180936.1_NCIM3186 | cds-NP_011444.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:366404-368476:+ | gene-YGL071W_NCYC1407 | rna-NM_001180936.1_NCYC1407 | cds-NP_011444.1_NCYC1407 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:368058-370130:+ | gene-YGL071W_PE2H3 | rna-NM_001180936.1_PE2H3 | cds-NP_011444.1_PE2H3 | 99.5 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:373096-375168:+ | gene-YGL071W_PE2H4 | rna-NM_001180936.1_PE2H4 | cds-NP_011444.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:372012-374084:+ | gene-YGL071W_S288C | rna-NM_001180936.1_S288C | cds-NP_011444.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000096.1:7162-9234:+ | gene-YGL071W_SA1 | rna-NM_001180936.1_SA1 | cds-NP_011444.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:366901-368973:+ | gene-YGL071W_ThermosaccDry | rna-NM_001180936.1_ThermosaccDry | cds-NP_011444.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:477282-479354:+ | gene-YGL071W_VR1 | rna-NM_001180936.1_VR1 | cds-NP_011444.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:364264-366336:+ | gene-YGL071W_ZTW1 | rna-NM_001180936.1_ZTW1 | cds-NP_011444.1_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:369865-371937:+ | gene-YGL071W_Sparadoxus | rna-NM_001180936.1_Sparadoxus | cds-NP_011444.1_Sparadoxus | 86.9 | 99.2 | Verified | 1 | 1 | 1 | False | True | False | False | False |