Gene name: AFG3
Reference locus (S288C): YER017C
Gene biotype: protein_coding
Description: Mitochondrial respiratory chain complexes assembly protein AFG3; Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging; expression of human homolog AFG3L2 can complement yeast yta12 afg3 double mutant; In the N-terminal section; belongs to the AAA ATPase family
Top 10 interactors (score): YTA12 (0.992); PHB2 (0.985); PHB1 (0.979); MBA1 (0.97); PIM1 (0.955); OMA1 (0.94); PCP1 (0.904); OXA1 (0.873); MGR3 (0.863); MRPL32 (0.86); SSC1 (0.831); MGR1 (0.823); YME1 (0.814); TIM10 (0.811); CCP1 (0.806); MCX1 (0.796); ATP12 (0.774); OCT1 (0.773); MIC27 (0.768); HSP60 (0.768)
Homologues (species, bitscore): AFG3L2 (Homo sapiens, 671.4); Afg3l2 (Mus musculus, 672.5); afg3l2 (Danio rerio, 667.5); afg3l1p (Xenopus tropicalis, 666.8); CG6512 (Drosophila melanogaster, 647.1); spg-7 (Caenorhabditis elegans, 630.9); ftsh10 (Arabidopsis thaliana, 644.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:183537-185822:- | gene-YER017C_AKU4011 | rna-NM_001178908.1_AKU4011 | cds-NP_010933.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:240268-242553:+ | gene-YER017C_BG1 | rna-NM_001178908.1_BG1 | cds-NP_010933.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:191394-193679:- | gene-YER017C_Bruggeman | rna-NM_001178908.1_Bruggeman | cds-NP_010933.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:186284-188569:- | gene-YER017C_CAT1 | rna-NM_001178908.1_CAT1 | cds-NP_010933.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:183460-185745:- | gene-YER017C_CBS1585 | rna-NM_001178908.1_CBS1585 | cds-NP_010933.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:185047-187332:- | gene-YER017C_CBS436 | rna-NM_001178908.1_CBS436 | cds-NP_010933.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:183704-185989:- | gene-YER017C_CBS6412 | rna-NM_001178908.1_CBS6412 | cds-NP_010933.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:188490-190775:- | gene-YER017C_CBS6413 | rna-NM_001178908.1_CBS6413 | cds-NP_010933.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:187392-189677:- | gene-YER017C_CENPK1137D | rna-NM_001178908.1_CENPK1137D | cds-NP_010933.1_CENPK1137D | 98.7 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:184163-186448:- | gene-YER017C_EthanolRed | rna-NM_001178908.1_EthanolRed | cds-NP_010933.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:184423-186708:- | gene-YER017C_FaliES1 | rna-NM_001178908.1_FaliES1 | cds-NP_010933.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000024.1:51047-53332:- | gene-YER017C_JAY291 | rna-NM_001178908.1_JAY291 | cds-NP_010933.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:187587-189872:- | gene-YER017C_MUCL30387 | rna-NM_001178908.1_MUCL30387 | cds-NP_010933.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:183862-186147:- | gene-YER017C_MUCL30388 | rna-NM_001178908.1_MUCL30388 | cds-NP_010933.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:182503-184788:- | gene-YER017C_MUCL39482 | rna-NM_001178908.1_MUCL39482 | cds-NP_010933.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:188618-190903:- | gene-YER017C_MUCL42920 | rna-NM_001178908.1_MUCL42920 | cds-NP_010933.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:189502-191787:- | gene-YER017C_NCIM3186 | rna-NM_001178908.1_NCIM3186 | cds-NP_010933.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:187575-189860:- | gene-YER017C_NCYC1407 | rna-NM_001178908.1_NCYC1407 | cds-NP_010933.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:191889-194174:- | gene-YER017C_PE2H3 | rna-NM_001178908.1_PE2H3 | cds-NP_010933.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:187788-190073:- | gene-YER017C_PE2H4 | rna-NM_001178908.1_PE2H4 | cds-NP_010933.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:189503-191788:- | gene-YER017C_S288C | rna-NM_001178908.1_S288C | cds-NP_010933.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000020.1:51896-54181:+ | gene-YER017C_SA1 | rna-NM_001178908.1_SA1 | cds-NP_010933.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:185194-187479:- | gene-YER017C_ThermosaccDry | rna-NM_001178908.1_ThermosaccDry | cds-NP_010933.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:183948-186233:- | gene-YER017C_VR1 | rna-NM_001178908.1_VR1 | cds-NP_010933.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:182406-184691:- | gene-YER017C_ZTW1 | rna-NM_001178908.1_ZTW1 | cds-NP_010933.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:186181-188460:- | gene-YER017C_Sparadoxus | rna-NM_001178908.1_Sparadoxus | cds-NP_010933.1_Sparadoxus | 90.2 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |