Gene name: AFG2
Reference locus (S288C): YLR397C
Gene biotype: protein_coding
Description: ATPase family gene 2 protein; ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; target of the ribosomal biosynthesis inhibitor diazaborine; may be involved in degradation of aberrant mRNAs
Top 10 interactors (score): RLP24 (0.997); ARX1 (0.997); NOG1 (0.99); RPN1 (0.989); NMD3 (0.987); NOG2 (0.987); BUD20 (0.987); RPT2 (0.986); YTM1 (0.985); PRE9 (0.984); UFD2 (0.984); SHP1 (0.984); YVH1 (0.983); ERB1 (0.983); REI1 (0.982); AFG1 (0.982); NPL4 (0.982); NSA1 (0.981); UBX4 (0.981); RPN2 (0.981)
Homologues (species, bitscore): SPATA5 (Homo sapiens, 578.9); Spata5 (Mus musculus, 577.0); vcp (Danio rerio, 486.5); spata5 (Xenopus tropicalis, 500.7); TER94 (Drosophila melanogaster, 479.9); cdc-48.2 (Caenorhabditis elegans, 470.3); AtCDC48C (Arabidopsis thaliana, 489.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:862086-864428:- | gene-YLR397C_AKU4011 | rna-NM_001182285.1_AKU4011 | cds-NP_013501.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:94232-96574:- | gene-YLR397C_BG1 | rna-NM_001182285.1_BG1 | cds-NP_013501.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:900391-902733:- | gene-YLR397C_Bruggeman | rna-NM_001182285.1_Bruggeman | cds-NP_013501.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:895918-898260:- | gene-YLR397C_CAT1 | rna-NM_001182285.1_CAT1 | cds-NP_013501.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:897682-900024:- | gene-YLR397C_CBS1585 | rna-NM_001182285.1_CBS1585 | cds-NP_013501.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:881323-883665:- | gene-YLR397C_CBS436 | rna-NM_001182285.1_CBS436 | cds-NP_013501.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:933723-936065:- | gene-YLR397C_CBS6412 | rna-NM_001182285.1_CBS6412 | cds-NP_013501.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:897973-900315:- | gene-YLR397C_CBS6413 | rna-NM_001182285.1_CBS6413 | cds-NP_013501.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:897361-899703:- | gene-YLR397C_CENPK1137D | rna-NM_001182285.1_CENPK1137D | cds-NP_013501.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:854629-856971:- | gene-YLR397C_EthanolRed | rna-NM_001182285.1_EthanolRed | cds-NP_013501.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:883939-886281:- | gene-YLR397C_FaliES1 | rna-NM_001182285.1_FaliES1 | cds-NP_013501.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000434.1:37099-39441:- | gene-YLR397C_JAY291 | rna-NM_001182285.1_JAY291 | cds-NP_013501.1_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:899257-901599:- | gene-YLR397C_MUCL30387 | rna-NM_001182285.1_MUCL30387 | cds-NP_013501.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:905343-907685:- | gene-YLR397C_MUCL30388 | rna-NM_001182285.1_MUCL30388 | cds-NP_013501.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:898902-901244:- | gene-YLR397C_MUCL39482 | rna-NM_001182285.1_MUCL39482 | cds-NP_013501.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:893558-895900:- | gene-YLR397C_MUCL42920 | rna-NM_001182285.1_MUCL42920 | cds-NP_013501.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:912524-914866:- | gene-YLR397C_NCIM3186 | rna-NM_001182285.1_NCIM3186 | cds-NP_013501.1_NCIM3186 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:908082-910424:- | gene-YLR397C_NCYC1407 | rna-NM_001182285.1_NCYC1407 | cds-NP_013501.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:894479-896821:- | gene-YLR397C_PE2H3 | rna-NM_001182285.1_PE2H3 | cds-NP_013501.1_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:894223-896565:- | gene-YLR397C_PE2H4 | rna-NM_001182285.1_PE2H4 | cds-NP_013501.1_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:912550-914892:- | gene-YLR397C_S288C | rna-NM_001182285.1_S288C | cds-NP_013501.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:133796-136138:+ | gene-YLR397C_SA1 | rna-NM_001182285.1_SA1 | cds-NP_013501.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:887018-889360:- | gene-YLR397C_ThermosaccDry | rna-NM_001182285.1_ThermosaccDry | cds-NP_013501.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:899569-901911:- | gene-YLR397C_VR1 | rna-NM_001182285.1_VR1 | cds-NP_013501.1_VR1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:223732-226074:- | gene-YLR397C_ZTW1 | rna-NM_001182285.1_ZTW1 | cds-NP_013501.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:872422-874764:- | gene-YLR397C_Sparadoxus | rna-NM_001182285.1_Sparadoxus | cds-NP_013501.1_Sparadoxus | 89.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |