Gene name: ADK1
Reference locus (S288C): YDR226W
Gene biotype: protein_coding
Description: Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant
Top 10 interactors (score): AMD1 (0.991); ADO1 (0.991); YNK1 (0.983); FAP7 (0.979); ADE13 (0.975); APT1 (0.967); APT2 (0.949); PYK2 (0.934); CDC19 (0.93); RNR1 (0.92); RNR2 (0.908); THI80 (0.901); RNR4 (0.901); YND1 (0.901); PDE2 (0.901); PDE1 (0.9); ADK2 (0.837); MNP1 (0.788); AAH1 (0.782); PHO81 (0.777)
Homologues (species, bitscore): AK2 (Homo sapiens, 269.2); Ak2 (Mus musculus, 272.3); ak2 (Danio rerio, 259.2); ak2 (Xenopus tropicalis, 270.0); Adk2 (Drosophila melanogaster, 265.0); let-754 (Caenorhabditis elegans, 250.4); At5g63400 (Arabidopsis thaliana, 251.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:873187-873855:+ | gene-YDR226W_AKU4011 | rna-NM_001180534.1_AKU4011 | cds-NP_010512.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:251978-252646:- | gene-YDR226W_BG1 | rna-NM_001180534.1_BG1 | cds-NP_010512.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:905505-906173:+ | gene-YDR226W_Bruggeman | rna-NM_001180534.1_Bruggeman | cds-NP_010512.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:892782-893450:+ | gene-YDR226W_CAT1 | rna-NM_001180534.1_CAT1 | cds-NP_010512.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:863538-864206:+ | gene-YDR226W_CBS1585 | rna-NM_001180534.1_CBS1585 | cds-NP_010512.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:892547-893215:+ | gene-YDR226W_CBS436 | rna-NM_001180534.1_CBS436 | cds-NP_010512.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:860296-860964:+ | gene-YDR226W_CBS6412 | rna-NM_001180534.1_CBS6412 | cds-NP_010512.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:890898-891566:+ | gene-YDR226W_CBS6413 | rna-NM_001180534.1_CBS6413 | cds-NP_010512.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:915287-915955:+ | gene-YDR226W_CENPK1137D | rna-NM_001180534.1_CENPK1137D | cds-NP_010512.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:873878-874546:+ | gene-YDR226W_EthanolRed | rna-NM_001180534.1_EthanolRed | cds-NP_010512.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:882080-882748:+ | gene-YDR226W_FaliES1 | rna-NM_001180534.1_FaliES1 | cds-NP_010512.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000348.1:28824-29492:- | gene-YDR226W_JAY291 | rna-NM_001180534.1_JAY291 | cds-NP_010512.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:891154-891822:+ | gene-YDR226W_MUCL30387 | rna-NM_001180534.1_MUCL30387 | cds-NP_010512.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:879408-880076:+ | gene-YDR226W_MUCL30388 | rna-NM_001180534.1_MUCL30388 | cds-NP_010512.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:864941-865609:+ | gene-YDR226W_MUCL39482 | rna-NM_001180534.1_MUCL39482 | cds-NP_010512.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:804227-804895:+ | gene-YDR226W_MUCL42920 | rna-NM_001180534.1_MUCL42920 | cds-NP_010512.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:916409-917077:+ | gene-YDR226W_NCIM3186 | rna-NM_001180534.1_NCIM3186 | cds-NP_010512.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:868611-869279:+ | gene-YDR226W_NCYC1407 | rna-NM_001180534.1_NCYC1407 | cds-NP_010512.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:884839-885507:+ | gene-YDR226W_PE2H3 | rna-NM_001180534.1_PE2H3 | cds-NP_010512.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:890120-890788:+ | gene-YDR226W_PE2H4 | rna-NM_001180534.1_PE2H4 | cds-NP_010512.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:916486-917154:+ | gene-YDR226W_S288C | rna-NM_001180534.1_S288C | cds-NP_010512.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000013.1:122594-123262:+ | gene-YDR226W_SA1 | rna-NM_001180534.1_SA1 | cds-NP_010512.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:880234-880902:+ | gene-YDR226W_ThermosaccDry | rna-NM_001180534.1_ThermosaccDry | cds-NP_010512.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:895443-896111:+ | gene-YDR226W_VR1 | rna-NM_001180534.1_VR1 | cds-NP_010512.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000007.1:142951-143619:+ | gene-YDR226W_ZTW1 | rna-NM_001180534.1_ZTW1 | cds-NP_010512.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:885251-885919:+ | gene-YDR226W_Sparadoxus | rna-NM_001180534.1_Sparadoxus | cds-NP_010512.1_Sparadoxus | 92.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |