Gene name: ADE3
Reference locus (S288C): YGR204W
Gene biotype: protein_coding
Description: Trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ade3; C-1-tetrahydrofolate synthase, cytoplasmic; Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase; involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
Top 10 interactors (score): SHM2 (0.998); ADE8 (0.996); SHM1 (0.996); ADE16 (0.988); MET13 (0.987); ADE17 (0.987); GCV1 (0.985); FAU1 (0.984); MET7 (0.978); ADE1 (0.972); ADE5,7 (0.966); CDC21 (0.964); DFR1 (0.959); MET12 (0.957); MTD1 (0.951); MIS1 (0.948); ADE2 (0.946); RMA1 (0.945); SRP40 (0.942); FMT1 (0.936)
Homologues (species, bitscore): MTHFD1 (Homo sapiens, 1078.5); Mthfd1 (Mus musculus, 1072.8); mthfd1b (Danio rerio, 1052.0); mthfd1l (Xenopus tropicalis, 818.5); pug (Drosophila melanogaster, 998.8); K07E3.4 (Caenorhabditis elegans, 749.2); THFS (Arabidopsis thaliana, 733.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:871458-874298:+ | gene-YGR204W_AKU4011 | rna-NM_001181333.3_AKU4011 | cds-NP_011720.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:151872-154712:+ | gene-YGR204W_BG1 | rna-NM_001181333.3_BG1 | cds-NP_011720.3_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:879662-882502:+ | gene-YGR204W_Bruggeman | rna-NM_001181333.3_Bruggeman | cds-NP_011720.3_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:877656-880496:+ | gene-YGR204W_CAT1 | rna-NM_001181333.3_CAT1 | cds-NP_011720.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:874898-877738:+ | gene-YGR204W_CBS1585 | rna-NM_001181333.3_CBS1585 | cds-NP_011720.3_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:878254-881094:+ | gene-YGR204W_CBS436 | rna-NM_001181333.3_CBS436 | cds-NP_011720.3_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:865769-868609:+ | gene-YGR204W_CBS6412 | rna-NM_001181333.3_CBS6412 | cds-NP_011720.3_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:871827-874667:+ | gene-YGR204W_CBS6413 | rna-NM_001181333.3_CBS6413 | cds-NP_011720.3_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:905660-908500:+ | gene-YGR204W_CENPK1137D | rna-NM_001181333.3_CENPK1137D | cds-NP_011720.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:860277-863117:+ | gene-YGR204W_EthanolRed | rna-NM_001181333.3_EthanolRed | cds-NP_011720.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:864668-867508:+ | gene-YGR204W_FaliES1 | rna-NM_001181333.3_FaliES1 | cds-NP_011720.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000148.1:22399-25239:+ | gene-YGR204W_JAY291 | rna-NM_001181333.3_JAY291 | cds-NP_011720.3_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:877147-879987:+ | gene-YGR204W_MUCL30387 | rna-NM_001181333.3_MUCL30387 | cds-NP_011720.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:876831-879671:+ | gene-YGR204W_MUCL30388 | rna-NM_001181333.3_MUCL30388 | cds-NP_011720.3_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:869972-872812:+ | gene-YGR204W_MUCL39482 | rna-NM_001181333.3_MUCL39482 | cds-NP_011720.3_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:887525-890365:+ | gene-YGR204W_MUCL42920 | rna-NM_001181333.3_MUCL42920 | cds-NP_011720.3_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:905934-908774:+ | gene-YGR204W_NCIM3186 | rna-NM_001181333.3_NCIM3186 | cds-NP_011720.3_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:865630-868470:+ | gene-YGR204W_NCYC1407 | rna-NM_001181333.3_NCYC1407 | cds-NP_011720.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:890240-893080:+ | gene-YGR204W_PE2H3 | rna-NM_001181333.3_PE2H3 | cds-NP_011720.3_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:895350-898190:+ | gene-YGR204W_PE2H4 | rna-NM_001181333.3_PE2H4 | cds-NP_011720.3_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:905934-908774:+ | gene-YGR204W_S288C | rna-NM_001181333.3_S288C | cds-NP_011720.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000101.1:27391-30231:+ | gene-YGR204W_SA1 | rna-NM_001181333.3_SA1 | cds-NP_011720.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:885179-888019:+ | gene-YGR204W_ThermosaccDry | rna-NM_001181333.3_ThermosaccDry | cds-NP_011720.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:989668-992508:+ | gene-YGR204W_VR1 | rna-NM_001181333.3_VR1 | cds-NP_011720.3_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:186627-189467:+ | gene-YGR204W_ZTW1 | rna-NM_001181333.3_ZTW1 | cds-NP_011720.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:877158-879998:+ | gene-YGR204W_Sparadoxus | rna-NM_001181333.3_Sparadoxus | cds-NP_011720.3_Sparadoxus | 91.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |