Gene name: ACO1
Reference locus (S288C): YLR304C
Gene biotype: protein_coding
Description: Aconitate hydratase, mitochondrial; Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; human homolog ACO2 can complement yeast null mutant
Top 10 interactors (score): FUM1 (0.999); CIT1 (0.999); IDH1 (0.999); IDH2 (0.999); CIT2 (0.998); KGD1 (0.996); MDH1 (0.994); ATP2 (0.994); CIT3 (0.993); ICL1 (0.993); CYT1 (0.992); TPI1 (0.991); PDB1 (0.99); ATP1 (0.988); SDH2 (0.987); IDP1 (0.987); KGD2 (0.986); AAT1 (0.984); LSC1 (0.983); TOM40 (0.98)
Homologues (species, bitscore): ACO2 (Homo sapiens, 1072.0); Aco2 (Mus musculus, 1078.9); aco2 (Danio rerio, 1076.2); aco2 (Xenopus tropicalis, 843.2); Acon (Drosophila melanogaster, 1070.5); aco-2 (Caenorhabditis elegans, 1080.5); T3P4.5 (Arabidopsis thaliana, 228.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:683659-685995:- | gene-YLR304C_AKU4011 | rna-NM_001182192.1_AKU4011 | cds-NP_013407.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000170.1:46629-48965:+ | gene-YLR304C_BG1 | rna-NM_001182192.1_BG1 | cds-NP_013407.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:719489-721825:- | gene-YLR304C_Bruggeman | rna-NM_001182192.1_Bruggeman | cds-NP_013407.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:717662-719998:- | gene-YLR304C_CAT1 | rna-NM_001182192.1_CAT1 | cds-NP_013407.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:718585-720921:- | gene-YLR304C_CBS1585 | rna-NM_001182192.1_CBS1585 | cds-NP_013407.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:703202-705538:- | gene-YLR304C_CBS436 | rna-NM_001182192.1_CBS436 | cds-NP_013407.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:681225-683561:- | gene-YLR304C_CBS6412 | rna-NM_001182192.1_CBS6412 | cds-NP_013407.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:719251-721587:- | gene-YLR304C_CBS6413 | rna-NM_001182192.1_CBS6413 | cds-NP_013407.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:719826-722162:- | gene-YLR304C_CENPK1137D | rna-NM_001182192.1_CENPK1137D | cds-NP_013407.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:676937-679273:- | gene-YLR304C_EthanolRed | rna-NM_001182192.1_EthanolRed | cds-NP_013407.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:706137-708473:- | gene-YLR304C_FaliES1 | rna-NM_001182192.1_FaliES1 | cds-NP_013407.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000296.1:59348-61684:+ | gene-YLR304C_JAY291 | rna-NM_001182192.1_JAY291 | cds-NP_013407.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:718723-721059:- | gene-YLR304C_MUCL30387 | rna-NM_001182192.1_MUCL30387 | cds-NP_013407.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:724306-726642:- | gene-YLR304C_MUCL30388 | rna-NM_001182192.1_MUCL30388 | cds-NP_013407.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:719815-722151:- | gene-YLR304C_MUCL39482 | rna-NM_001182192.1_MUCL39482 | cds-NP_013407.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:714972-717308:- | gene-YLR304C_MUCL42920 | rna-NM_001182192.1_MUCL42920 | cds-NP_013407.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:735186-737522:- | gene-YLR304C_NCIM3186 | rna-NM_001182192.1_NCIM3186 | cds-NP_013407.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:729157-731493:- | gene-YLR304C_NCYC1407 | rna-NM_001182192.1_NCYC1407 | cds-NP_013407.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:716969-719305:- | gene-YLR304C_PE2H3 | rna-NM_001182192.1_PE2H3 | cds-NP_013407.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:716713-719049:- | gene-YLR304C_PE2H4 | rna-NM_001182192.1_PE2H4 | cds-NP_013407.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:735212-737548:- | gene-YLR304C_S288C | rna-NM_001182192.1_S288C | cds-NP_013407.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000039.1:46755-49091:+ | gene-YLR304C_SA1 | rna-NM_001182192.1_SA1 | cds-NP_013407.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:708031-710367:- | gene-YLR304C_ThermosaccDry | rna-NM_001182192.1_ThermosaccDry | cds-NP_013407.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:720180-722516:- | gene-YLR304C_VR1 | rna-NM_001182192.1_VR1 | cds-NP_013407.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:46458-48794:- | gene-YLR304C_ZTW1 | rna-NM_001182192.1_ZTW1 | cds-NP_013407.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:694133-696469:- | gene-YLR304C_Sparadoxus | rna-NM_001182192.1_Sparadoxus | cds-NP_013407.1_Sparadoxus | 94.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |