Gene name: ACE2
Reference locus (S288C): YLR131C
Gene biotype: protein_coding
Description: Metallothionein expression activator; Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
Top 10 interactors (score): CBK1 (0.992); FKH2 (0.97); CDC28 (0.953); MOB2 (0.952); CTS1 (0.944); FKH1 (0.942); MBP1 (0.925); HYM1 (0.921); CLB2 (0.904); SWI6 (0.904); SWI4 (0.903); CRM1 (0.895); NDD1 (0.891); ASH1 (0.888); MCM1 (0.888); SOG2 (0.872); KIC1 (0.86); CLB3 (0.833); AMN1 (0.829); TAO3 (0.827)
Homologues (species, bitscore): KLF16 (Homo sapiens, 78.2); Klf15 (Mus musculus, 79.0); klf13 (Danio rerio, 82.4); sp1 (Xenopus tropicalis, 78.6); Bteb2 (Drosophila melanogaster, 70.5); klf-2 (Caenorhabditis elegans, 71.2); YY1 (Arabidopsis thaliana, 51.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:386989-389301:- | gene-YLR131C_AKU4011 | rna-NM_001182018.1_AKU4011 | cds-NP_013232.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:350774-353086:- | gene-YLR131C_BG1 | rna-NM_001182018.1_BG1 | cds-NP_013232.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:398872-401184:- | gene-YLR131C_Bruggeman | rna-NM_001182018.1_Bruggeman | cds-NP_013232.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:398284-400595:- | gene-YLR131C_CAT1 | rna-NM_001182018.1_CAT1 | cds-NP_013232.1_CAT1 | 99.7 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:394133-396445:- | gene-YLR131C_CBS1585 | rna-NM_001182018.1_CBS1585 | cds-NP_013232.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:384374-386686:- | gene-YLR131C_CBS436 | rna-NM_001182018.1_CBS436 | cds-NP_013232.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:392550-394862:- | gene-YLR131C_CBS6412 | rna-NM_001182018.1_CBS6412 | cds-NP_013232.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:394398-396710:- | gene-YLR131C_CBS6413 | rna-NM_001182018.1_CBS6413 | cds-NP_013232.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:389532-391844:- | gene-YLR131C_CENPK1137D | rna-NM_001182018.1_CENPK1137D | cds-NP_013232.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:387190-389502:- | gene-YLR131C_EthanolRed | rna-NM_001182018.1_EthanolRed | cds-NP_013232.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:386701-389013:- | gene-YLR131C_FaliES1 | rna-NM_001182018.1_FaliES1 | cds-NP_013232.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000117.1:4177-6488:+ | gene-YLR131C_JAY291 | rna-NM_001182018.1_JAY291 | cds-NP_013232.1_JAY291 | 99.9 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:398864-401176:- | gene-YLR131C_MUCL30387 | rna-NM_001182018.1_MUCL30387 | cds-NP_013232.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:403683-405995:- | gene-YLR131C_MUCL30388 | rna-NM_001182018.1_MUCL30388 | cds-NP_013232.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:394642-396954:- | gene-YLR131C_MUCL39482 | rna-NM_001182018.1_MUCL39482 | cds-NP_013232.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:394772-397084:- | gene-YLR131C_MUCL42920 | rna-NM_001182018.1_MUCL42920 | cds-NP_013232.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:404484-406796:- | gene-YLR131C_NCIM3186 | rna-NM_001182018.1_NCIM3186 | cds-NP_013232.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:386914-389226:- | gene-YLR131C_NCYC1407 | rna-NM_001182018.1_NCYC1407 | cds-NP_013232.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:392484-394796:- | gene-YLR131C_PE2H3 | rna-NM_001182018.1_PE2H3 | cds-NP_013232.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:392225-394537:- | gene-YLR131C_PE2H4 | rna-NM_001182018.1_PE2H4 | cds-NP_013232.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:404510-406822:- | gene-YLR131C_S288C | rna-NM_001182018.1_S288C | cds-NP_013232.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000055.1:30421-32733:- | gene-YLR131C_SA1 | rna-NM_001182018.1_SA1 | cds-NP_013232.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:387911-390223:- | gene-YLR131C_ThermosaccDry | rna-NM_001182018.1_ThermosaccDry | cds-NP_013232.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:400626-402937:- | gene-YLR131C_VR1 | rna-NM_001182018.1_VR1 | cds-NP_013232.1_VR1 | 99.9 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:385709-388021:- | gene-YLR131C_ZTW1 | rna-NM_001182018.1_ZTW1 | cds-NP_013232.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:395821-398130:- | gene-YLR131C_Sparadoxus | rna-NM_001182018.1_Sparadoxus | cds-NP_013232.1_Sparadoxus | 89.0 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |